Antiplasmodial Activity and Phytochemical Constituents of Selected Antimalarial Plants Used by Native People in West Timor Indonesia

TAEK, Maximus M. and TUKAN, Gerardus D. (2021) Antiplasmodial Activity and Phytochemical Constituents of Selected Antimalarial Plants Used by Native People in West Timor Indonesia. Turkish Journal of Pharmaceutical Sciences, 18 (1). pp. 80-90. ISSN -

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Abstract

Objectives: To document traditional antimalarial plants used by Tetun ethnic people in West Timor Indonesia and evaluate the antiplasmodial activity and phytochemicals of several plants that are widely used as oral medicine. Materials and Methods: A field study to document antimalarial plants followed by laboratory works to test antiplasmodial activity and identify the phytochemical constituents of some selected plants extract were applied. The inhibitory potency of ethanolic extracts of Strychnos ligustrina wood, roots of Calotropis gigantea, Fatuoa pilosa, and Neoalsomitra podagrica, whole plant of Cleome rutidosperma and Physalis angulata, stem barks of Alstonia spectabilis, Alstonia scholaris, Jatropha curcas and Plumeria alba, and leaves of Melia azedarach on the Plasmodium falciparum 3D7 strain in vitro were tested. Gas chromatography-mass spectrometry instrument was used to analyze the phytochemicals of the extracts. Results: The Tetun ethnic people use 50 plant species as antimalarials. P. angulata, J. curcas, and A. spectabilis extracts show strong antiplasmodial activity with IC50 values of 0.22, 0.22, and 1.23 μg/mL, respectively; N. podagrica, A. scholaris, F. pilosa, and P. alba were moderate antiplasmodials with IC50 values of 11.60, 15.46, 24.92, and 36.39 μg/mL, respectively; and C. rutidosperma, M. azedarach, S. ligustrina, and C. gigantea were weak antiplasmodials with IC50 values of 54.25, 63.52, 63.91, and 66.49 μg/mL, respectively. The phytochemicals identification data indicate that these 11 plants contain alkaloids, terpenoids, steroids, coumarins, alcohols, thiols, phenolics, aldehydes, fatty acids, esters, and so forth. Conclusion: Plants widely used as antimalarials by the Tetun ethnic people is proven to have antiplasmodial activity.

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