Senyawa-Senyawa Metabolit Sekunder Tumbuhan Yang Berpotensi Menghambat Infeksi Covid-19

PAJI, Umpriadus Umbu (2020) Senyawa-Senyawa Metabolit Sekunder Tumbuhan Yang Berpotensi Menghambat Infeksi Covid-19. Undergraduate thesis, Universitas Katolik Widya Mandira.

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Abstract

Covid-19 virus or Severa acute respiratory syndrome Coronavirus-2 (SARS-CoV-2 has four structural proteins, namely protein S (spike), E (envelope), M (membrane), and N (nucleocapsid). N protein holds the RNA genome, while the S, E, and M proteins together form the viral envelope. These proteins play a role in the process of firus covid-19 infection in host cells, so this study is to determine the various types of natural compounds that have the potential to inhibit COVID-19 infection by using how to stop the activity of ACE-2 receptors, Protein S, Protease, Replicase, DNMTS and Methyltransferases RNA. The methods used in this study are literature studies and in silico. The results of this study, found 136 compounds that could potentially inhibit COVID-19 infection by stopping activity protein in viruses These compounds are found in seven groups of compounds, which are identified as follows: quercetin (from the flavonoid group), glycyrrhizin (from the saponin group)), curcumin (from the phenolic group), beta-sitosterol (from the steroid class), suginol (from the terpenoid class), cassameridine (from the alkaloid class), and rosmariquinone (from the diterpenoid class).These compounds are found in various types of plants, namely: broccoli, green tea, carrots, leeks, oranges, turmeric, green chilies and various other plants. The mechanism of action in inhibiting target receptors with these compounds is through molecular action, including 3CLpro (3C and other major proteases), papain (PLpro), RNA-dependent RNA polymerase (RdRp), helicase, TMPRSS2, ACE2 and Spike glycoproteins all binds well to the anti-SARS-CoV-2 compound.

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